Larry Nordone, Sen. Darline Graham, R-S.C. and Sen. Tim Scott, R-S.C. applaud as President Donald Trump speaks during a campaign rally at the T. Ed Garrison Arena, Wednesday, Oct. 21, 2026, in Pendleton, S.C.
Julia Demaree Nikhinson/AP
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In a stunning upset in typically reliably Republican South Carolina, CNN’s Decision Desk is projecting that Democrat Annie Andrews will defeat President Donald Trump’s hand-picked candidate Sen. Darline Graham.

Andrews is flipping a seat Republicans have held for nearly three decades and a state that voted for Trump by nearly 18 percentage points in 2024. But the result has been building since Graham became the GOP nominee in late August.