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Down a dim, crooked hallway inside the Jay Street Lofts, a hulking brick relic of Brooklyn’s industrial past, Naomi Mishkin is conducting a radical fashion experiment.

She’s making shirts. In New York City. Using cotton and wool. They are not cheap, and they never go on sale. That counts as a rebellious act in the sprawling $1.9 trillion global fashion industry, a business that over the past three decades has mastered the art of cutting production costs to the bone.